This study investigates how systemic therapy affects cognitive functioning in older women who have undergone breast cancer treatment. Cognitive functioning refers to mental processes like thinking, learning, memory, and problem-solving. Researchers aim to understand if and how these treatments impact these abilities.

Participants in this study will undergo various assessments to evaluate their cognitive functions. These assessments may include interviews and neuropsychological tests to measure different aspects of cognitive health. Participants may also choose to take part in optional neuroimaging studies, which involve taking pictures of the brain to look for changes.

• Who can participate: Healthy women aged 60 and above who have never had cancer, are English-speaking, and can communicate well enough to complete study assessments. Participants must not have a history of neurodegenerative disorders, major depressive disorder, or other severe mental health conditions.
• Study details: Participants will be involved in cognitive assessments, which may include interviews and tests to measure mental abilities. Some participants may also choose to participate in neuroimaging studies, which are scans that take pictures of the brain.