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A Phase II study of Concurrent Chemoradiation plus Durvalumab (MEDI4736) followed by Surgery followed by Adjuvant Durvalumab (MEDI4736) in medically operable patients with surgically resectable Stage III (N2) Non-Small Cell Lung Cancer

Investigating Treatment for Stage IIIA Non-Small Cell Lung Cancer with Chemotherapy, Radiation, and Surgery

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18 years and older
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This study investigates the treatment of Stage IIIA non-small cell lung cancer (NSCLC) using a combination of chemotherapy, radiation therapy, and surgery. NSCLC is a type of lung cancer that includes subtypes such as adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. The study aims to understand the effectiveness of combining these treatments with an investigational medication to manage the disease.

Participants will receive chemotherapy and radiation therapy at the same time, followed by surgery to remove the cancer. After surgery, they will continue to receive the investigational medication to see if it helps keep the cancer from returning. This process involves various medical procedures to monitor the patient's response to the treatment.

  • Who can participate: Adults with Stage IIIA (N2) non-small cell lung cancer amenable to surgical removal and without distant metastasis can participate. Adequate organ function is required, and no prior treatment for NSCLC is allowed.
  • Study details: Participants will undergo chemotherapy and radiation therapy, followed by surgical removal of the cancer. Post-surgery, they will receive the investigational medication as maintenance therapy. A placebo is not used in this study.
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Study details
    Non-Small Cell Lung Cancer

TX10373

19 February 2024

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