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An Open-Label, Multicenter, Phase 1 Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Ascending Intravenous Doses of Inhibrx rhAAT-Fc (INBRX-101) in Adults with Alpha-1 Antitrypsin Deficiency (AATD)

Study on Safety and Tolerability of Investigational Medication for Alpha-1 Antitrypsin Deficiency (AATD)

Recruiting
18-70 years
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This study investigates the safety and tolerability of an investigational medication in patients with Alpha-1 Antitrypsin Deficiency (AATD). AATD is a genetic condition that can cause lung and liver problems. The purpose of this study is to understand how the investigational medication affects individuals with this condition.

Participants will undergo procedures such as bronchoscopies, which involve using a thin tube to look inside the lungs. All study procedures will take place at University Hospital, and participants will receive compensation for their time and effort.

  • Who can participate: Adults diagnosed with Alpha-1 Antitrypsin Deficiency who are non-smokers and willing to undergo 2 bronchoscopies can participate. Participants must be willing to pause their current AATD treatment for about 5 months.
  • Study details: Participants will take part in study procedures at University Hospital, including undergoing bronchoscopies. A bronchoscopy is a procedure that uses a thin tube to examine the lungs. Participants will be compensated for their time and effort.
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Study details
    Alpha-1 Antitrypsin Deficiency (AATD)

TX10435

19 February 2024

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