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An open-label, Phase II, platform trial evaluating safety and efficacy of multiple BI 754091 anti-PD-1 based combination regimens in PD-(L)1 naïve and PD-(L)1 pretreated patient populations with advanced and/or metastatic solid tumours who have had at least one line of systemic therapy

Study of Investigational Medications in Advanced Solid Tumors

Recruiting
18 years and older
All

This study investigates the effects of investigational medications in individuals with advanced or metastatic solid tumors. Advanced or metastatic solid tumors are cancers that have spread from their original location to other parts of the body. The study will examine the combination of two investigational drugs to assess their potential impact on these types of tumors.

Participants in the study will undergo procedures such as pre-treatment and on-treatment tumor biopsies. A biopsy is a medical test involving the removal of cells or tissues for examination. These procedures are essential for understanding how the investigational drugs interact with the tumor cells.

  • Who can participate: Adults with advanced or metastatic solid tumors who agree to undergo biopsies are eligible. Participants must use effective birth control during the trial and for six months after.
  • Study details: Participants will receive a combination of investigational medications. They will need to have biopsies before and during the treatment to assess the effects of the medications.
Study details
    Solid Tumor

TX10498

19 February 2024

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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