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Repetitive Transcranial Magnetic Stimulation as a Probe of Episodic Memory Neurocircuitry in Schizophrenia

Investigating Brain Imaging and Magnetic Stimulation in Schizophrenia

Recruiting
18-40 years
All

This study investigates the use of brain imaging and magnetic stimulation in individuals with schizophrenia. Schizophrenia is a mental health disorder that affects how a person thinks, feels, and behaves. The study uses functional magnetic resonance imaging (fMRI) to take pictures of the brain while using repetitive transcranial magnetic stimulation (rTMS), which involves sending magnetic pulses to the brain. The study aims to understand how different frequencies of magnetic stimulation might affect brain activity in schizophrenia.

Participants in the study will undergo brain imaging and receive two types of magnetic stimulation: low frequency and high frequency. Low frequency stimulation is thought to reduce brain activity, while high frequency stimulation may increase it. This study will help researchers learn more about how these methods can be used together to study schizophrenia.

  • Who can participate: Adults aged 18 to 40 years who have been diagnosed with schizophrenia and are within 10 years of the onset of the illness can participate. Participants must be clinically stable, able to give informed consent, and willing to follow the study schedule. They should not have a history of seizures, significant neurological illness, or be pregnant.
  • Study details: Participants will undergo brain imaging and receive magnetic stimulation treatments. Some will receive low frequency stimulation, while others will receive high frequency stimulation. The study will use a placebo for comparison, which is an inactive substance that looks like the investigational treatment but does not contain any active medicine.
Study details
    Schizophrenia

TX10563

19 February 2024

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