This study investigates the effects of radiation and chemotherapy compared to radiation alone in treating salivary gland cancer. Salivary gland cancer affects the glands that produce saliva, and this study aims to find out which treatment is better at reducing the chance of the cancer returning.

Participants will undergo several procedures, including physical exams, blood tests, and imaging scans. They will be divided into two study arms: one receiving only radiation therapy and the other receiving radiation plus chemotherapy. The study will monitor participants' health through regular tests and evaluations.

• Who can participate: Adults 18 years or older with resected high-risk malignant salivary gland tumors can participate. Those with previous chemotherapy or radiation for this cancer, severe co-morbidities, significant hearing loss, or who are pregnant are not eligible.
• Study details: Participants will be randomly assigned to receive either radiation therapy alone or with chemotherapy. Radiation is given daily, while chemotherapy is weekly for 7 weeks. A placebo is not used in this study.