This study investigates how the pH level in the airway may affect people with asthma and cystic fibrosis. It looks at how acid in the airway can change the body's response to infections and increase inflammation, which might make usual treatments less effective. The study aims to find a simpler way to measure airway pH, which is currently done using a bronchoscopy, a procedure involving inserting a camera into the airway.
Participants will undergo a screening process and baseline characterization. They will take part in a non-invasive challenge test using an inhaled alkaline glycine buffer. Afterward, repeated measurements of airway function and inflammation will be taken, along with a research bronchoscopy.
- Who can participate: Adults aged 18 to 50 with asthma or cystic fibrosis can participate if they have had no recent flares or changes in medication. Participants must be available for 3-4 clinic visits over 4-6 weeks.
- Study details: Participants will attend clinic visits and are responsible for undergoing tests such as a non-invasive challenge test and a bronchoscopy.
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