This study investigates asthma, a common condition where some patients do not respond well to traditional treatments. This may be due to high levels of a protein called GSNOR that reduces GSNO, a chemical that helps relax airway muscles. When GSNO levels are low, airway muscles can tighten, leading to symptoms such as coughing, wheezing, and shortness of breath. The purpose of this study is to identify patients with high levels of GSNOR to develop a practical method for targeting this process.
Participants will undergo several procedures including screening, baseline characterization, a research bronchoscopy, and a non-invasive challenge test with inhaled GSNO. This will be followed by repeated measurements of airway function and inflammation. A bronchoscopy is a procedure where a doctor looks at the airways through a thin viewing instrument called a bronchoscope.
- Who can participate: This study is for individuals aged 18 to 50 years who have asthma. Participants should not have had recent asthma flare-ups or changes in medication. They should be available for 3-4 clinic visits over 2-6 weeks.
- Study details: Participants will take part in screening and baseline tests, followed by a bronchoscopy and a challenge test with inhaled GSNO. A bronchoscopy involves using a thin tube to look inside the airways.
- Study Timelines and Visits: The study will last 2-6 weeks. The study requires 3-4 visits.
