GSNOR Phenotyping/GSNO Challenge in Severe Asthma

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Updated on 19 February 2024

Summary

This is a three to four visit study, spanning approximately two to six weeks, in which subjects with asthma and healthy volunteers will undergo screening, baseline characterization, a research bronchoscopy, and a non-invasive challenge test with inhaled GSNO followed by repeated measurements of airway function and inflammation.  

Description

Asthma is common but some people don’t respond to traditional treatments. This could be
because some asthma patients have high levels of a protein (GSNOR) that reduces the amount
of a chemical that relaxes airway muscles (GSNO) in their body. This can lead to the airway
muscles tightening which can cause symptoms like coughing, wheezing and shortness of
breath. There may be drugs that can target this process but first we must identify which patients
have high levels of this protein. We are developing a practical method to do just that.
For more information, call us at 317-274-3380 or email IUasthma@iupui.edu

FAQ

For more information, call us at 317-274-3380 or email IUasthma@iupui.edu

Details
Condition asthma
Age 18years - 50years
Clinical Study IdentifierTX11043
Last Modified on19 February 2024

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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