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A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients with Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer

Investigation of Reduced-Dose Radiation Therapy for Oropharyngeal Cancer

Recruiting
18 years and older
All
Phase 2/3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates treatments for squamous cell carcinoma of the oropharynx, a type of throat cancer. The purpose is to compare different therapies using reduced-dose radiation. Participants will receive either radiation with cisplatin, a chemotherapy drug, or radiation with nivolumab, an immunotherapy drug.

Participants will be randomly assigned to one of the study arms. This means they will either receive radiation with cisplatin or radiation with nivolumab. The study aims to evaluate the effectiveness and safety of these treatments compared to the standard therapy.

  • Who can participate: Adults aged 18 and older with squamous cell carcinoma of the oropharynx can participate. Those with a smoking history over 10 pack-years, severe co-morbidities, or who are pregnant are not eligible.
  • Study details: Participants will be randomly assigned to receive radiation therapy with either cisplatin or nivolumab. A placebo is not used in this study.
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Study details
    Oropharyngeal Cancer

NCT03952585

19 February 2024

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