Optimizing Subcutaneous FEntanyl titRation: RApid Achievement of Adequate Exposure When Treating Cancer-Related paIn.

  • STATUS
    Recruiting
  • participants needed
    45
  • sponsor
    Erasmus Medical Center
Send
Updated on 20 November 2025
See if I qualify

Summary

The primary objective is to evaluate the effect of loading boluses when dose incresaing treatment with SC fentanyl in patients with cancer. The primary endpoint of this study is to prove the non-inferiority of fentanyl plasma concentrations 12 hours after dose augmentation compared to 48 hours after dose augmentation within each patient.

Patients will be treated with additional loading boluses and plasma-PK samples will be obtained.

Details
Condition Cancer Pain
Age 18years - 120years
Clinical Study IdentifierNCT06498037
SponsorErasmus Medical Center
Last Modified on20 November 2025

Eligibility

 Yes No Not Sure

Inclusion Criteria

Age ≥18 years
Able to understand the written information and able to give informed consent
Current or planned treatment with SC fentanyl for cancer-related pain

Exclusion Criteria

Pregnancy or/ and breastfeeding
Other ways of using fentanyl (sublingual, nasal spray and oromucosal)
Liver function CPS B or C
The use of strong CYP3A4 inhibitors of inducers [9]
Presence of somnolence, respiratory depression or CTCAE grade 2 adverse events
Clear my responses
Read more

How to participate?

Step 1 Connect with a study center
Message sent successfully.
We have submitted the information you provided to the research team at the location you chose. For your records, we have sent a copy of the message to your email address.
If you would like to be informed of other studies that may be of interest to you, you may sign up for Patient Notification Service.
Sign up

Send a message

Enter your contact details to connect with study team

Email

View email

Phone

Phone country flag

View phone
Investigator Avatar

Primary Contact

First name*
Last name*
Email*
Phone number*
Preferred way of contact label
Race
Ethnicity
Other language

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.