Clinical Outcomes and Host Immune Response in Vascular Graft and Endograft Infections

  • STATUS
    Enrolling By Invitation
  • End date
    Sep 1, 2033
  • participants needed
    300
  • sponsor
    Aarhus University Hospital
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Updated on 15 July 2026
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Accepts healthy volunteers

Summary

ACHIEVE is a prospective observational cohort and biobank study of patients with suspected or diagnosed central vascular graft or endograft infection. The study also includes patients undergoing elective central vascular graft or endograft implantation and healthy blood donor controls. Participants undergo longitudinal clinical data collection and biospecimen sampling. The study aims to characterize clinical outcomes, host immune responses, inflammatory biomarkers, pathogen-related factors, and novel microbiological diagnostic methods, including microbial cell-free DNA sequencing, in vascular graft and endograft infections.

Details
Condition Vascular Graft Infection, Vascular Endograft Infection, Aortic Graft Infection
Age 18years or above
Clinical Study IdentifierNCT07696884
SponsorAarhus University Hospital
Last Modified on15 July 2026

Eligibility

 Yes No Not Sure

Inclusion Criteria

Age 18 years or older
Able and willing to provide informed consent
For the vascular graft or endograft infection group: suspected or diagnosed vascular graft or endograft infection in a central vascular prosthesis as determined by the treating clinicians
For the elective vascular graft or endograft control group: planned central vascular graft or endograft implantation
For the healthy blood donor control group: active blood donor registered at Aarhus University Hospital Blood Bank
For the healthy blood donor control group: no current infection or other active disease

Exclusion Criteria

For the elective vascular graft or endograft control group: surgery performed as an emergency procedure within 24 hours
For the elective vascular graft or endograft control group: reoperation of a previously implanted vascular graft or endograft
For the elective vascular graft or endograft control group: evidence suggestive of ongoing infection in the area of surgery
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