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Phase 2 Trial of XL184 (Cabozantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases in Children and Young Adults With Refractory Sarcomas Wilms Tumor and Other Rare Tumors

Investigation of Investigational Medication in Treating Rare Tumors in Young Patients

Recruiting
2-30 years
All
Phase N/A

This study investigates how well an investigational medication works in treating young patients with sarcomas, Wilms tumor, or other rare tumors. These tumors may have returned, not responded to therapy, or been newly diagnosed. The purpose is to determine the rate at which these tumors respond to the investigational medication.

Participants in this study will undergo specific procedures to evaluate the effectiveness of the treatment. The study will assess the objective response, which includes complete and partial responses to the investigational medication. Participants will not receive payment for their involvement in the study.

  • Who can participate: Participants must be 50 years old or younger. They should not have received specific treatments, like XL184 or certain other inhibitors, and must meet specific health criteria regarding previous treatments and current conditions, including not having significant cardiac arrhythmias or active infections.
  • Study details: Participants will take the investigational medication and their response will be monitored. Specific monitoring procedures will be in place to track participants' response to the investigational medication. A placebo is not used in this study.
Study details
    sarcomas
    Wilms tumor

TX7854

19 February 2024

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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