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A Pilot Study of Pembrolizumab in Combination With Y90 Radioembolization in Subjects With Poor Prognosis Hepatocellular Carcinoma With Preserved Liver Function. HCRN: GI15-225

Study on the Effects of Investigational Medication with Radioembolization (a procedure using tiny radioactive beads to target cancer cells in the liver) for Liver Cancer

Recruiting
18 years and older
All
Phase N/A
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  • Technical description (Original)

This study investigates the effects of an investigational medication combined with Yttrium-90 radioembolization for patients with advanced liver cancer, specifically hepatocellular carcinoma. This type of cancer affects the liver and is considered advanced when it cannot be treated with surgery or liver transplant. The study aims to understand how well this combination works and its safety for people with a poor prognosis but stable liver function.

Participants in the study will receive the investigational medication along with a treatment called Yttrium-90 radioembolization. This involves using tiny radioactive beads to target cancer cells in the liver. The study will monitor the effects of this combination treatment to gather information on its safety and effectiveness.

  • Who can participate: Adults with advanced liver cancer, specifically hepatocellular carcinoma, who cannot have surgery or a liver transplant. Participants must not have extrahepatic metastatic disease and must have adequate organ function.
  • Study details: Participants will receive an investigational medication combined with Yttrium-90 radioembolization. A placebo will not be used in this study.
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Study details
    hepatocellular carcinoma

TX8124

19 February 2024

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