This study investigates the use of a haploidentical transplant, a type of allogeneic transplant, to see if it is safe and effective for treating sickle cell disease (SCD). Sickle cell disease is a condition where red blood cells are shaped like a sickle, which can cause pain and other serious problems. A haploidentical transplant involves using a donor who is a half-match to the recipient, which might offer more treatment options for patients.
Participants in the study will undergo a procedure where bone marrow is transplanted from a donor who is a close family member. This process is called a haploidentical transplant. The study will monitor the safety and effectiveness of this procedure in treating SCD. Participants will be compensated for their involvement in the study.
- Who can participate: Adults with adequate physical function who have a first-degree relative willing to donate bone marrow can participate. Those with an HLA-matched sibling donor, uncontrolled infections, previous HCT, participation in another research study recently, pregnancy, or uncontrolled autoimmune diseases cannot join.
- Study details: Participants will receive a haploidentical transplant from a related donor. This involves transferring bone marrow from a family member who is a partial genetic match.
