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A Phase 1a/1b Study of an Anti-IDO-1 Agent (LY3381916) Administered Alone or in Combination with Anti-PD-L1 Checkpoint Antibody (LY3300054) in Solid Tumors

Investigation of Safety of an Investigational Medication Alone or with an Antibody

Recruiting
18 years and older
All
Phase N/A

The purpose of this study is to investigate the safety of an investigational medication when given alone or with an antibody that targets a protein called PD-L1. PD-L1 is involved in the body's immune response, and targeting it can help enhance the body's ability to fight cancer. This study focuses on individuals with advanced or metastatic cancer, which means the cancer has spread to other parts of the body.

Participants in this study will receive either the investigational medication by itself or in combination with the antibody targeting PD-L1. The study will monitor the safety of these treatments and gather information on any side effects. Participants will need to swallow capsules as part of the treatment process.

  • Who can participate: Adults with advanced or metastatic cancer who have stopped previous cancer treatments and have adequate organ function can participate. They must have an ECOG performance status of 1 or less and be able to swallow capsules.
  • Study details: Participants will take the investigational medication alone or with a PD-L1 targeting antibody. A placebo is not used in this study.
Study details
    urothelial carcinoma
    non small cell lung cancer

TX8313

19 February 2024

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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