A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients

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Updated on 19 February 2024

Summary

This phase II trial studies how well reduced doses of radiation therapy to the brain and spine (craniospinal) and chemotherapy work in treating patients with newly diagnosed type of brain tumor called WNT)/Wingless (WNT)-driven medulloblastoma.

Description

The purpose of this study is to estimate the progression-free survival (PFS) of children >= 3 years of age with wingless-type MMTV integration site family (WNT)/WNT-driven average-risk medulloblastoma using reduced craniospinal radiotherapy (CSI) (18 Gray [Gy]) with a limited target volume boost to the tumor bed of 36 Gy for a total of 54 Gy and reduced chemotherapy approach (no vincristine [vincristine sulfate] during radiotherapy and reduced-dose maintenance chemotherapy) and to monitor the PFS for early evidence that the outcome is unacceptable.
Participants will not be paid for their participation.

FAQ

Participants will not be paid for their participation.

Details
Condition Untreated Childhood Medulloblastoma,Medulloblastoma ,pediatric,riley,kid,kids,child,children,teen,teens,teenager,teenagers,adolescent,youth
Age 3years - 21years
Clinical Study IdentifierTX8337
Last Modified on19 February 2024

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