This study investigates the relationship between body composition, which includes muscle and fat mass, and the side effects experienced by patients undergoing a common chemotherapy treatment. This treatment is used for individuals with advanced, metastatic, or recurrent pancreatic cancer, a condition where cancer cells form in the tissues of the pancreas.

Participants in the study will undergo specific procedures to assess their body composition and monitor any side effects from the chemotherapy regimen. This will help researchers understand how different body compositions might affect the side effects experienced during treatment.

• Who can participate: Adults with locally advanced, metastatic, or recurrent pancreatic ductal adenocarcinoma may participate. They must be planning to receive first or second line therapy with the specified chemotherapy regimen and have an ECOG Performance Status of 0-2.
• Study details: Participants will receive an investigational treatment regimen and will be monitored for side effects. The study will involve assessments of muscle and fat mass to see how these factors relate to treatment side effects.