This study investigates the use of pre-operative stereotactic radiosurgery followed by surgery in patients with brain metastases. Brain metastases occur when cancer cells spread to the brain from another part of the body. The goal is to evaluate how well this treatment approach controls the cancer in the brain six months after treatment.

Participants will undergo a procedure called stereotactic radiosurgery, which is a type of radiation therapy that precisely targets brain tumors. This will be followed by surgical removal of the tumor within 1 to 3 days. The study will assess the effectiveness of this treatment in controlling the brain metastases.

• Who can participate: Adults with 1 to 4 brain metastases confirmed by MRI or CT scan, who are candidates for both radiosurgery and surgical resection, are eligible. Patients must not have received anti-VEGF therapy within 6 weeks prior to the study.
• Study details: Participants will receive stereotactic radiosurgery, followed by surgery to remove brain tumors. This study does not involve a placebo.