This study investigates the effectiveness of two methods for breast cancer screening: digital tomosynthesis mammography and digital mammography. The purpose of this study is to compare how often advanced breast cancer occurs in participants who are screened using these two methods over a period of 4.5 years. Digital tomosynthesis mammography is a type of breast imaging that creates a three-dimensional picture of the breast, while digital mammography is a standard two-dimensional imaging technique.

Participants in the study will undergo either digital tomosynthesis mammography or digital mammography as part of the screening process. These imaging techniques are used to look for signs of breast cancer in women who do not have any symptoms. The study will take place at facilities qualified by the American College of Radiology Imaging Network. Participants will not receive any payment for their involvement in the study.

• Who can participate: Women who are not pregnant or breastfeeding and are scheduled for a screening mammogram can participate. Participants must not have any symptoms of breast disease and should not have had a mammogram in the last 11 months. Women with a previous history of breast cancer or breast enhancements are not eligible.
• Study details: Participants will undergo either digital tomosynthesis mammography or digital mammography. These procedures involve imaging the breast to detect any signs of cancer. The study will be conducted at facilities qualified by the American College of Radiology Imaging Network.
• Study Timelines: The study will last 4.5 years.