This study investigates the effectiveness of nephrectomy, a surgery to remove a kidney or part of it, with or without an investigational medication in patients with localized kidney cancer. The purpose is to compare how long patients remain free of cancer recurrence after treatment. Localized kidney cancer means the cancer is limited to a specific area and has not spread to other parts of the body.
Participants in this study will undergo either surgery alone or surgery combined with the investigational medication. The investigational medication is used to see if it can improve outcomes when given around the time of surgery. Nephrectomy can be either radical, removing the entire kidney, or partial, removing only the affected part.
- Who can participate: Adults aged 18 years or older with newly diagnosed, higher risk renal cell carcinoma (RCC) of any histology, including sarcomatoid, are eligible to participate.
- Study details: Participants will either have surgery alone or surgery with an investigational medication. The investigational medication is given around the time of surgery to evaluate if it improves outcomes.
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