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A Phase II Study to Evaluate the Safety Pharmacodynamics and Efficacy of Entinostat in Combination with Nivolumab plus Ipilimumab in Patients with Renal Cell Carcinoma Previously Treated with Nivolumab plus Ipilimumab

Study on Safety and Effects of Combining Investigational Medications for Renal Cell Carcinoma

Recruiting
18 years and older
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates the safety of combining investigational medications with immune checkpoint inhibitors in patients with renal cell carcinoma. Renal cell carcinoma is a type of kidney cancer. The purpose of the study is to see how these medications affect tumors that have not responded to certain treatments.

Participants will receive a combination of investigational medications. The study will measure how many patients experience tumor shrinkage. Participants will undergo various procedures to assess their response to the treatment.

  • Who can participate: Adults with renal cell carcinoma that has spread and worsened despite previous treatment with specific immune checkpoint inhibitors may participate. Participants must have measurable disease, completed prior cancer treatment at least 28 days before joining, and have adequate organ function and a life expectancy of at least 6 months.
  • Study details: Participants will receive investigational medications combined with immune checkpoint inhibitors.
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Study details
    renal cell carcinoma
    kidney cancer

TX8870

19 February 2024

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