This study investigates whether MRI scans of the brain can identify infants who will experience withdrawal symptoms after being exposed to opioids before birth. The study aims to find differences in brain structure and function using MRI in infants who have been exposed to opioids compared to those who have not been exposed. Additionally, it seeks to identify differences in those exposed infants who require further opioid treatment after birth and those who do not.

Participants will undergo MRI procedures to assess brain differences. MRI, or Magnetic Resonance Imaging, is a test that uses magnets and radio waves to create pictures of organs and tissues inside the body. This study will compare the MRI results of infants with different levels of opioid exposure and treatment needs.

• Who can participate: Mothers aged over 18 years with a history of opioid misuse and their infants born after 36 weeks are eligible, provided the mothers are enrolled in a prenatal opioid maintenance program. Infants must be less than or equal to 48 weeks corrected gestational age at the time of MRI. Exclusion criteria include mothers and infants with significant medical complications or other drug dependencies. Healthy mothers with no drug use and their infants can also participate as controls.
• Study details: Participants will have MRI scans of their infants' brains to study differences related to opioid exposure. A placebo is not involved in this study.