This study investigates how well chemotherapy works in treating children and young adults with liver cancer, specifically hepatoblastoma and hepatocellular carcinoma, after surgery. Hepatoblastoma is a rare liver cancer that occurs in children, while hepatocellular carcinoma is a more common type of liver cancer that can affect young adults. The purpose of this study is to reduce the side effects of therapy for patients with non-metastatic liver cancer without affecting their long-term health outcomes.

Participants in this study will undergo surgery to remove the liver tumor. Depending on the type of cancer cells found in the tumor, some patients may receive no additional chemotherapy, while others may receive two cycles of a chemotherapy drug called cisplatin. Chemotherapy uses powerful drugs to kill cancer cells and is often given in cycles to allow the body to recover between treatments.

• Who can participate: Children and young adults newly diagnosed with hepatoblastoma or hepatocellular carcinoma can participate. Patients must not have received prior chemotherapy or any tumor-directed therapy.
• Study details: Participants will undergo surgery to remove the liver tumor. Some may receive cisplatin chemotherapy, which is given in cycles.