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A Phase 1 First-in-Human Open-label Study Evaluating the Safety Tolerability Pharmacokinetics and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With a Specific KRAS Mutation.

Investigating the Effects of an Investigational Medication for Advanced Solid Tumors with KRAS Mutation

Recruiting
18 years and older
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates the effects of an investigational medication for treating advanced solid tumors with a specific KRAS mutation. These are tumors that have a change in the KRAS gene, which can cause cancer cells to grow. The study is in Phase 1, which means it is the first time the medication is being tested in humans to see if it is safe and how it affects the body.

Participants will undergo procedures to assess the safety and effectiveness of the investigational medication. This includes monitoring how the body processes the medication, known as pharmacokinetics, and evaluating any side effects or benefits. The study will involve providing tumor samples, either from previous collections or through a new biopsy, to help researchers understand how the medication works.

  • Who can participate: Adults 18 years and older with advanced solid tumors and a specific KRAS mutation can participate. They must have tried standard treatments or be unable to benefit from them. Tumor samples are required for study participation.
  • Study details: Participants will receive the investigational medication and may need to provide tumor samples. A placebo, which is an inactive substance, is not used in this study.
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Study details
    Cancer
    Solid Tumor

TX9005

19 February 2024

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