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A Phase II Study of Combining Talimogene Laherparepvec T-VEC (NSC-785349) and MK-3475 (Pembrolizumab) (NSC-776864) in Patients With Advanced Melanoma Who Have Progressed on Anti-PD1/L1 Based Therapy

Study on the Effects of an Investigational Medication Combination in Skin Cancer (Melanoma) Patients

Recruiting
18 years and older
All
Phase N/A

This study investigates the effects of a combination of investigational medications in patients with melanoma. Melanoma is a type of skin cancer that can spread to other parts of the body. The purpose of this study is to evaluate how well this combination works in patients who have already tried other treatments.

Participants in the study will receive a combination of two investigational medications. These medications will be given to see if they can provide a durable response in treating melanoma. The study will involve regular monitoring to assess the effects of the treatment.

  • Who can participate: Adults with stage IV or unresectable stage III melanoma can participate. Patients must not have disease suitable for local therapy, and those with treated brain metastases may join if there is no disease progression and no steroid use for 14 days prior.
  • Study details: Participants will receive a combination of investigational medications and be monitored to evaluate the response to the treatment. No payment will be provided for participation.
Study details
    melanoma

TX9307

19 February 2024

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