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Phase III Randomized Study of Crenolanib versus Midostaurin Administered Following Induction Chemotherapy and Consolidation Therapy in Newly Diagnosed Subjects with FLT3 Mutated Acute Myeloid Leukemia

Investigational Medication for Acute Myeloid Leukemia with FLT3 Mutation

Recruiting
18-60 years
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates the treatment of acute myeloid leukemia (AML) in patients with a specific genetic change called FLT3 mutation. The purpose is to compare two investigational medications given after initial and follow-up chemotherapy, as well as after bone marrow transplant, to see which is more effective in extending the time patients remain free of cancer events.

Participants will receive either one of the two investigational medications after their chemotherapy sessions. The study involves monitoring the patients' health and response to the medication to evaluate its effectiveness and safety.

  • Who can participate: Adults diagnosed with de novo acute myeloid leukemia (AML) with a FLT3 mutation can participate. Participants must have adequate liver and kidney function before starting chemotherapy.
  • Study details: Participants will receive one of the investigational medications after chemotherapy sessions. A placebo is not used in this study.
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Study details
    Acute Myeloid Leukemia

TX9327

19 February 2024

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