Randomized Trial of Standard Chemotherapy Alone or Combined With Atezolizumab as Adjuvant Therapy for Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

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Updated on 19 February 2024

Summary

This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair.

Description

The purpose of this study is to determine whether atezolizumab combined with oxaliplatin, leucovorin calcium, and fluorouracil (FOLFOX) and its continuation as monotherapy can significantly improve disease-free survival (DFS) compared to FOLFOX alone in patients with stage III colon cancers and deficient DNA mismatch repair (dMMR).
Participants will not be paid for their participation.

FAQ

Participants will not be paid for their participation.

Details
Condition DNA repair disorder,Lynch Syndrome,colon cancer
Age 18years - 100years
Clinical Study IdentifierTX9374
Last Modified on19 February 2024

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