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A study of Hematopoietic Stem Cell Transplantation (HSCT) in Non-Malignant Disease using a Reduced-Intensity preparatory regime with Campath-1H Fludarabine and Melphalan

Investigation of Bone Marrow Transplantation for Non-Cancerous Diseases

Recruiting
1-21 years
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates the use of bone marrow transplantation to treat diseases that are not cancer. Bone marrow transplantation involves replacing damaged or diseased bone marrow with healthy bone marrow stem cells. This is done to improve the function of the patient's blood and immune system.

Participants in this study will undergo a procedure that involves receiving stem cells from a donor. The donor's stem cells can come from bone marrow, peripheral blood, or cord blood. The study aims to evaluate how well this treatment works in improving the health of patients with specific non-cancerous diseases.

  • Who can participate: Participants must be under 21 years old and have a non-cancerous disorder that benefits from stem cell transplantation. They must have a suitable donor and meet specific health criteria.
  • Study details: Participants will receive stem cells from a donor, which can be from bone marrow, peripheral blood, or cord blood. The study will assess the effectiveness of this treatment in improving patient health.
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Study details
    Sickle Cell Disease
    Thalassemia

TX782

19 February 2024

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