SARC024; A Blanket Protocol to Study Oral Regorafenib in Patients With Refractory Liposarcoma Osteogenic Sarcoma and Ewing/Ewing-like Sarcomas

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Updated on 19 February 2024

Summary

The purpose of this study is to examine regorafenib in a systematic fashion in patients with other forms of sarcoma.

Description

Although regorafenib was approved for use in patients who had progressive GIST despite imatinib and/or sunitinib on the basis of phase II and phase III data, it has not been examined in a systematic fashion in patients with other forms of sarcoma. Given the activity of sorafenib, sunitinib and pazopanib in soft tissue sarcomas, and evidence of activity of sorafenib in osteogenic sarcoma and possibly Ewing/Ewing-like sarcoma, there is precedent to examine SMOKIs (small molecule oral kinase inhibitors) such as regorafenib in sarcomas other than GIST. It is also recognized that SMOKIs (small molecule oral kinase inhibitors)such as regorafenib, sorafenib, pazopanib, and sunitinib have overlapping panels of kinases that are inhibited simultaneously. While not equivalent, most of these SMOKIs (small molecule oral kinase inhibitors) block vascular endothelial growth factor and platelet derived growth factors receptors (VEGFRs and PDGFRs), speaking to a common mechanism of action of several of these agents.

Participants will not be paid for their participation.

FAQ

Participants will not be paid for their participation.

Details
Condition Liposarcoma
Age 18years - 100years
Clinical Study IdentifierTX4073
Last Modified on19 February 2024

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