A Randomized Phase II Trial of Brentuximab Vedotin (SGN35 NSC# 749710) or Crizotinib (NSC#749005 Commercially Labeled) in Combination With Chemotherapy for Newly Diagnosed Patients With Anaplastic Large Cell Lymphoma (ALCL)

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Updated on 19 February 2024

Summary

This partially randomized phase II trial studies how well brentuximab vedotin or crizotinib and combination chemotherapy works in treating patients with newly diagnosed stage II-IV anaplastic large cell lymphoma.

Description

The purpose of this study is to determine the tolerability of brentuximab vedotin given in combination with standard chemotherapy (anaplastic large cell lymphoma [ALCL]99) and to determine the tolerability of crizotinib given in combination with chemotherapy (ALCL99); and to estimate the event free survival (EFS) of Arm brentuximab vedotin (BV) and Arm crizotinib (CZ) and contrast these to historical control data.

Participants will not be paid for their participation.

FAQ

Participants will not be paid for their participation.

Details
Condition Anaplastic Large Cell Lymphoma (ALCL),Anaplastic Large Cell Lymphoma,ALCL,Large Cell Lymphoma,Large Cell,Lymphoma,Cancer,Oncology,Pediatric,Kid,Kids,Teen,Teens,Teenager,Teenagers,Child,Children,Adolescent,Youth
Age 21years or below
Clinical Study IdentifierTX5876
Last Modified on19 February 2024

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