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Using Functional Image and Circulating Molecular Markers to Predict Tumor Control and Thoracic Toxicity in Treatment of Lung Cancer

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Updated on 19 February 2024

Summary

The purpose of this study is to see if these scans help predict how well the treatment works for your cancer, how well your lungs, esophagus and heart function during treatment, and if treatment causes inflammation (irritation, swelling, redness due to injury).

Description

The purpose of this study is to determine if tumor metabolic activity plus volume measured by 18F-FDG PET/CT and tissue/tumor perfusion measured by 62Cu-ETS-PET before and during treatment predicts CT tumor response 3 months after completion of treatment and 1 and 2 year local-regional progression-free survival; to determine if functional imaging based lung dose-volume histograms (DVH) more accurately predict changes in diffusion capacity of lung for carbon monoxide (DLCO) compared to the DVH based on simulationg CT; and to determine if baseline level, or changes in blood markers such as TGFbeta1 measured during the course of radiation, predict changes in DLCO.

Details
Condition lung cancer
Age 18years - 100years
Clinical Study IdentifierTX7661
Last Modified on19 February 2024

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