Risk-Stratified Randomized Phase III Testing of Blinatumomab (NSC#765986) in First Relapse of Childhood B-Lymphoblastic Leukemia (B-ALL)

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Updated on 19 February 2024

Summary

This randomized phase III trial compares how well blinatumomab works compared with standard combination chemotherapy in treating patients with B-cell acute lymphoblastic leukemia that has returned after a period of improvement (relapsed).

Description

The purpose of this study is to compare disease free survival (DFS) of high-risk (HR) and intermediate-risk (IR) relapse B-cell acute lymphoblastic leukemia (B-ALL) patients who are randomized following induction block 1 chemotherapy to receive either two intensive chemotherapy blocks or two 5-week blocks of blinatumomab (HR/IR randomization), and to compare the DFS of low risk (LR) relapse B-ALL patients who are randomized following block 2 chemotherapy to receive either chemotherapy alone or chemotherapy plus blinatumomab (LR randomization).

Participants will not be paid for their participation.

FAQ

Participants will not be paid for their participation.

Details
Condition Relapsed B-cell Acute Lymphoblastic Leukemia (B-ALL),Relapsed B-cell Acute Lymphoblastic Leukemia,B-ALL,relapsed,acute lymphoblastic leukemia,lymphoblastic leukemia,leukemia,lymphoblastic,cancer,oncology,childhood,child,children,kid,kids,teen,teens,teenager,teenagers,adolescent,youth,riley
Age 1years - 30years
Clinical Study IdentifierTX4663
Last Modified on19 February 2024

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