This study investigates the causes of diabetes related to the pancreas, such as chronic pancreatitis or pancreatic cancer, compared to type 2 diabetes. Diabetes mellitus is a condition characterized by high blood sugar levels. This study aims to develop a test to distinguish between diabetes caused by pancreatic issues and type 2 diabetes.

Participants will undergo various procedures to help develop this test. These procedures may involve holding certain diabetes medications on the day of a meal tolerance test. The study will include different study arms to compare participants with new onset diabetes, long-standing diabetes, and those without diabetes.

• Who can participate: Adults who have been diagnosed with either new onset diabetes or long-standing diabetes, with or without pancreatic disease, are eligible. Non-diabetic individuals with or without pancreatic disease may also participate.
• Study details: Participants will be involved in a meal tolerance test where some diabetes medications may need to be paused. Those on low doses of insulin may not take it on the day of the test. Participants will be compensated for their involvement.