Phase 2 Study of Imatinib in Children with Neurofibromatosis and Airway Tumors

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Updated on 19 February 2024

Summary

The purpose of this study is to look at a subset of plexiform neurofibromas and determine if the airway tumors are more sensitive to imatinib therapy.

Description

The purpose of this study is to determine if NF1 associated pediatric airway-related plexiform neurofibromas represent a subset of plexiform neurofibromas with an inherent sensitivity to imatinib therapy and if imatinib therapy will show efficacy by improving respiratory function as assessed by pulmonary function tests and sleep study evaluations as children with airway tumors.

Participants will be paid for their participation.

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Participants will be paid for their participation.

Details
Condition neurofibromas
Age 1years - 12years
Clinical Study IdentifierTX5482
Last Modified on19 February 2024

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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