This study investigates the effects of neutralizing a certain protein in the skin and blood of patients with atopic dermatitis, a condition causing red and itchy skin. The study aims to see if the response to this neutralization differs among various subtypes of atopic dermatitis.

Participants will undergo procedures to assess the effects of protein neutralization. These procedures will help determine differences in response among the subtypes of atopic dermatitis.

• Who can participate: The study is open to individuals with active moderate to severe atopic dermatitis and healthy individuals matched in age, race, and sex. Key exclusions include recent use of systemic immunosuppressants, phototherapies, or certain topical treatments, and a history of specific medical conditions.
• Study details: Participants will take part in procedures to neutralize a protein in their skin and blood. A placebo, which is an inactive substance that looks like the investigational medication but does not contain any medicine, may be used.