Development of a cellular model of chemotherapy-induced toxicity CIPN and CHF
-
- STATUS
- Not Recruiting
Summary
We are applying for data from dbGaP (http://www.ncbi.nlm.nih.gov/gap/). Access to this dataset requires approval from the investigator?s local institutional review board as part of the application process. Additionally full IRB review is required before access to data will be granted. Upon approval of the application, the investigators can download de-identified genotype and phenotype data from dbGaP.
The genomic data requested will be used in two ongoing projects our lab is currently working on. 1) In a prior randomized phase III breast cancer trial, our lab found through whole exome sequencing (WES) that deleterious mutations in gene SBF2 were associated with taxane-induced peripheral neuropathy (TIPN) in African Americans (AA). This finding led us to further explore and functionally validate the role of SBF2 in TIPN using human induced pluripotent stem cells (iPSC)-derived sensory neurons from genetically confirmed AAs. 2) Our lab has also identified a single nucleotide variance associated with the development of congestive heart failure (CHF) via genome-wide association study (GWAS) in breast cancer patients treated with anthracycline-based chemotherapy.
In this study, we will use this genomic data to identify iPSC cell lines with the SNP of interest to derive human iPSC-derived cardiomyocytes and neurons.
Description
We are applying for data from dbGaP (http://www.ncbi.nlm.nih.gov/gap/). Access to this dataset requires approval from the investigator?s local institutional review board as part of the application process. Additionally full IRB review is required before access to data will be granted. Upon approval of the application, the investigators can download de-identified genotype and phenotype data from dbGaP.
The genomic data requested will be used in two ongoing projects our lab is currently working on. 1) In a prior randomized phase III breast cancer trial, our lab found through whole exome sequencing (WES) that deleterious mutations in gene SBF2 were associated with taxane-induced peripheral neuropathy (TIPN) in African Americans (AA). This finding led us to further explore and functionally validate the role of SBF2 in TIPN using human induced pluripotent stem cells (iPSC)-derived sensory neurons from genetically confirmed AAs. 2) Our lab has also identified a single nucleotide variance associated with the development of congestive heart failure (CHF) via genome-wide association study (GWAS) in breast cancer patients treated with anthracycline-based chemotherapy.
In this study, we will use this genomic data to identify iPSC cell lines with the SNP of interest to derive human iPSC-derived cardiomyocytes and neurons.
Details
| Condition | breast cancer |
|---|---|
| Age | 100years or below |
| Clinical Study Identifier | TX9013 |
| Last Modified on | 19 February 2024 |
Similar trials to consider
Not finding what you're looking for?
Sign up as a volunteer to stay informed
Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.
Sign up as volunteerStudy Definition
WikipediaAdd a private note
- Select a piece of text.
- Add notes visible only to you.
- Send it to people through a passcode protected link.