This study investigates how often cancer is found when an excisional biopsy is done near an initial core biopsy. The initial core biopsy showed flat epithelial atypia (FEA) or intraductal papilloma without atypia (IPWA). Flat epithelial atypia is a condition where the cells lining the milk ducts of the breast look abnormal under a microscope, but are not cancer. Intraductal papilloma without atypia is a small, non-cancerous tumor that grows in a milk duct of the breast.

Participants in this study will undergo an excisional biopsy procedure. This means a small area of tissue will be removed for closer examination. The study will help determine how often cancer is detected in these cases. Participants will not receive any payment for joining the study.

• Who can participate: Individuals with an imaging abnormality requiring a core needle biopsy may participate. Participants must be registered within 60 days after the core needle biopsy. Those with a history of invasive breast cancer, palpable abnormality diagnosed by core needle biopsy to be FEA or IPWA, pathologic nipple discharge associated with IPWA, a BIRADS 5 lesion, discordance between the initial breast imaging finding and the core biopsy pathology report, the presence of atypical ductal hyperplasia on core biopsy, or current pregnancy are excluded. Women who are breastfeeding are also excluded.
• Study details: Participants will have an excisional biopsy, which involves removing a small piece of tissue for examination. This study does not involve any investigational medications or placebos. Participants will not receive any payment for participating in the study.