DREAMseq (Doublet, Randomized Evaluation in Advanced Melanoma Sequencing) a Phase III Trial

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Updated on 19 February 2024

Summary

This randomized phase III trial studies how well initial treatment with ipilimumab and nivolumab followed by dabrafenib and trametinib works and compares it to initial treatment with dabrafenib and trametinib followed by ipilimumab and nivolumab in treating patients with stage III-IV melanoma that contains a mutation known as v-raf murine sarcoma viral oncogene homolog B V600 (BRAFV600) and cannot be removed by surgery.

Description

The purpose of this study is to determine whether initial treatment with either combination ipilimumab-nivolumab (with subsequent dabrafenib in combination with trametinib) or dabrafenib in combination with trametinib (with subsequent ipilimumab-nivolumab) significantly improves 2 year overall survival (OS) in patients with unresectable stage III or stage IV BRAFV600 mutant melanoma.

Participants will not be paid for their participation.

FAQ

Participants will not be paid for their participation.

Details
Condition advanced melanoma,melanoma,cancer,oncology,skin cancer,malignant melanoma
Age 18years - 100years
Clinical Study IdentifierTX6105
Last Modified on19 February 2024

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