Found 168 clinical trials
Cancer Drug Development Program
Develop a new cancer drug targeting multiple types of tumors.
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- 28 May, 2025
PHASE III RANDOMIZED TRIAL OF STANDARD SYSTEMIC THERAPY (SST) VERSUS STANDARD SYSTEMIC THERAPY PLUS DEFINITIVE TREATMENT (SURGERY OR RADIATION) OF THE PRIMARY TUMOR IN METASTATIC PROSTATE CANCER
The purpose of this study is to compare the effects, good and/or bad, of adding either prostate removal surgery or radiation therapy to standard systemic therapy (SST), which is used to treat prostate cancer.
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- 19 Feb, 2024
- 1 location
A Phase Ib/II Clinical Study of BBI608 Administered With Paclitaxel in Adult Patients With Advanced Malignancies
This is an open label, single arm phase 1 dose escalation study and phase 2 study of BBI608 in combination with paclitaxel in patients with advanced malignancies.
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- 19 Feb, 2024
- 1 location
Total Cancer Care: A Lifetime Partnership with Patients Who Have or May be at Risk of Having Cancer
The purpose of this research study is to collect and store biospecimens and personal health information to use in future research studies. This research study is to build a large database (of information and specimens) to find better ways to prevent, diagnose and treat cancer.
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- 19 Feb, 2024
- 1 location
PHO-COG-FALLON-ANBL00B1; Neuroblastoma Biology Studies
This research trial studies biomarkers in tumor tissue samples from patients with newly diagnosed neuroblastoma or ganglioneuroblastoma.
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- 19 Feb, 2024
- 1 location
A COG Soft Tissue Sarcoma Biology and Banking Protocol
The purpose of this study is to better diagnose certain types of cancer.
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- 19 Feb, 2024
- 1 location
Phase 1b Multi-indication Study of Anetumab Ravtansine (BAY 94-9343) in Patients with Mesothelin Expressing Advanced or Recurrent Malignancies
The key purpose of the main part of the study is to assess efficacy and safety of anetumab ravtansine as monotherapy or combination therapy for mesothelin expressing advanced solid tumors.
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- 19 Feb, 2024
- 1 location
A Path Analysis Modeling of the Interaction of AXII and/or AXIIR with the Changes in Cytokines and Myeloma Bone Disease
The purpose of this research study is to learn if substances that cause bone destruction are increased in the blood or bone marrow.
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- 19 Feb, 2024
- 1 location
A Randomized Phase II Study of Partial Breast Irradiation and Sequential vs. Concurrent Chemotherapy in Women with ER Negative Early Stage Breast Cancer (PBI 3.0)
The purpose of this study is to determine whether giving partial breast irradiation and chemotherapy at the same time has the same side effects and outcomes as giving partial breast irradiation and chemotherapy at different times.
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- 19 Feb, 2024
- 1 location
Pre-Operative PARPi and Irradiation (POPI) in Women with an Incomplete Response to Neo Adjuvant Chemotherapy (NAC) for Breast Cancer.
The purpose of this study is to determine the number of participants who can handle the treatment within specific safety parameters, determine the number of participants who can handle safely the maximum tolerated dose (MTD) (within 50-200 mg/BID dose range) when combining Veliparib and radiation, as well as to identify …
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- 19 Feb, 2024
- 1 location