Found 511 clinical trials
Biomarkers of endothelial dysfunction in pediatric patients receiving high intensity chemotherapy/irradiation
The purpose of this study is to collect blood specimens and data from patients undergoing stem cell transplant.
Phase II Randomized Double-Blind Study of mFOLFIRINOX plus Ramucirumab versus mFOLFIRINOX plus placebo in Advanced Pancreatic Cancer Patients HCRN GI14-198
The purpose of this study is to find out what effects, good and/or bad, there are to adding the drug ramucirumab (RAM) to the usual chemotherapy regimen.
A Phase II Trial of Chemotherapy plus Pembrolizumab in patients with advanced NSCLC previously treated with PD-1 or PD-L1 Inhibitor
This is a single-arm phase II study of continuation immunotherapy with pembrolizumab following initial benefit with a PD-1 or PD-L1 inhibitor.
A Randomized Phase 3 Study of Vincristine Dactinomycin Cyclophosphamide (VAC) Alternating with Vincristine and Irinotecan (VI) Versus VAC/VI Plus Temsirolimus (TORI Torisel NSC# 683864 IND# 122782) in Patients with Intermediate Risk (IR) Rhabdomyosarcoma (RMS)
The purpose of this study is to compare the event-free survival of patients with IR RMS treated with surgery, radiotherapy and VAC alternating with VI (VAC/VI) to that of patients treated with surgery, radiotherapy and VAC/VI plus temsirolimus (TORI).
Observational Disease Registry of Patients Treated with Systemic Mold-Active Triazoles
This study seeks to describe representative real-world patterns of care for the management of invasive fungal infections (IFIs) ,including invasive mold infection (IMI). Specifically, the study goals are to examine real world patient characteristics and treatment patterns, associated healthcare resource utilization, and outcomes associated with use of mold-active triazoles (MATs) …
Comparative Effectiveness of Interventions to Improve Screening Among Rural Women
The purpose of this study is to compare the effectiveness of a tailored interactive DVD (TIDVD) vs telephone patient navigation (PN) + tailored interactive DVD (TIDVD) vs Usual Care in increasing screening rates for Breast Cancer (BC), Cervical Cancer (CC), and colorectal cancer (CRC) among women 50 -74 years living …
Pilot Study of Cabozantinib for Recurrent or Progressive High-Grade Glioma in Children
The purpose of this study is to find out if the drug, Cabozantinib, is safe and tolerable in pediatric patients with refractory and/or recurrent high grade gliomas (HGG) who have previously received radiation therapy. We are also looking to see if the drug has an effect on the rate at …
Observational Study for Pediatric Rheumatic Diseases: The CARRA Registry
The purpose of this study is to collect information regarding treatment plans and disease activity of current patients with pediatric onset rheumatic diseases, in the hopes that this information can help improve treatments and health outcomes for future patients.
Syncardia 50cc Temporary Total Artificial Heart(TAH-t) As A Bridge To Transplant (BTT)
The purpose of this study is to see if the investigational device can support people who are at imminent risk of death from biventricular heart failure, eligible for transplant, and for whom the 70cc Total Artificial Heart is not appropriate.
A Randomized Double-Blind Placebo-Controlled Multi-Center Pragmatic Clinical Trial to Evaluate Effectiveness of Low Dose Oral Methotrexate in Patients with Pediatric Crohn's Disease Initiating Anti-TNF Therapy (COMBINE Umbrella)
The purpose of this study is to determine whether, in children with Crohn?s disease (CD) initiating anti-TNF (anti-Tumor Necrosis Factor) biological therapy with infliximab or adalimumab, low-dose oral methotrexate (MTX) is more effective than placebo in the induction and subsequent maintenance of steroid-free remission for a treatment period of up …
