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Found 511 clinical trials

Phase II Trial of Atezolizumab in BCG-Unresponsive Non-muscle Invasive Bladder Cancer

This phase II trial studies how well atezolizumab works in treating patients with non-muscle invasive bladder cancer that has come back and has not responded to treatment with Bacillus Calmette-Guerin (BCG).

18 years and older
All
Phase N/A

Protocol for the collection and transfer of cystic fibrosis lungs for research purposes

The goal of this project is to secure lung, tissue and blood samples of no clinical or diagnostic value from patients with cystic fibrosis (CF), and provide them to qualified and approved medical researchers.

18 years and older
All
Phase N/A

Social Networks and Parenting Study

The purpose of this study is to understand how parents make decisions during pregnancy and after the birth of their new baby.

18 years and older
Female
Phase N/A

A First-in-Human Phase I Trial to Determine the Safety and the Pharmacokinetic Profile of DSP-0337 in Patients With Advanced Solid Tumors

This is a Phase 1, open label, multi-center study of orally administered DSP-0337 in adult subjects with advance solid tumors that are refractory to standard treatment, or for whom no effective therapy exists.

18 years and older
All
Phase N/A

A Randomized Phase II Study of Pembrolizumab an anti-PD (programmed cell death)-1 Antibody in Combination with Carboplatin Compared to Carboplatin Alone in Breast Cancer Patients with Chest Wall Disease

This study is being done to see what effects the combination of pembrolizumab and carboplatin have on breast cancer compared to carboplatin alone.

18 years and older
All
Phase N/A

A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or Crizotinib Added to Intensive Therapy for Children With Newly Diagnosed High-Risk Neuroblastoma (NBL)

The purpose of this study is to look at iobenguane I-131 or crizotinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma.

1-30 years
All
Phase N/A

Online activities among transgender community

The purpose of this study is to observe how transgender people in the United States use online spaces and to provide analysis of how trans people create their own knowledge about intersectional relations of gender through their speech and practices on the Internet.

13 years and older
All
Phase N/A

A Phase II Study to Evaluate the Safety Pharmacodynamics and Efficacy of Entinostat in Combination with Nivolumab plus Ipilimumab in Patients with Renal Cell Carcinoma Previously Treated with Nivolumab plus Ipilimumab

This study is being done to test the safety of combining Entinostat with Nivolumab and Ipilimumab. It will also measure the percentage of patients whose tumor shrank after receiving Entinostat with Nivolumab and Ipilimumab.

18 years and older
All
Phase N/A

Cardiac Vagal Effects of Gastric Electrical Stimulation and Vagal Nerve Action Potentials in Vagus nerve in Patients with Gastroparesis- Randomized Phase

The purpose of this study is to assess if the Gastric Electric Stimulator (GES) device may influence the vagal output, which helps in the relief of the symptoms of gastroparesis, mainly nausea and vomiting.

18 years and older
All
Phase N/A

Reduced Intensity Conditioning for Haploidentical Bone Marrow Transplantation in Patients with Symptomatic Sickle Cell Disease

The researchers are doing this study to learn if a new type of transplant is safe and effective to treat Severe Sickle Cell Disease (SCD).

5-45 years
All
Phase N/A

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