Found 511 clinical trials
A RANDOMIZED, PHASE II STUDY COMPARING TRASTUZUMAB AND VINORELBINE IN COMBINATION WITH AVELUMAB OR AVELUMAB AND UTOMILUMAB (41BB/CD137 AGONIST), IN PATIENTS WITH HER2-POSITIVE METASTATIC BREAST CANCER WHO HAVE PROGRESSED ON PRIOR TRASTUZUMAB AND PERTUZUMAB: The "AVIATOR" Study
To determine whether the addition of avelumab to the combination of trastuzumab and vinorelbine will improve progression-free survival (PFS) compared to the trastuzumab and vinorelbine combination alone in patients with advanced HER2-positive breast cancer. To determine whether the addition of utomilumab to the combination of avelumab, trastuzumab, and vinorelbine will …
A Phase 3, Randomized, Open-label, Multicenter Study Comparing Ponatinib Versus Imatinib, Administered in Combination With Reduced-Intensity Chemotherapy, in Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
The primary objective of the study is to compare the efficacy of ponatinib versus imatinib, administered as first-line therapy in combination with reduced-intensity chemotherapy, in patients with newly diagnosed Ph+ ALL, as measured by the MRD-negative CR rate at the end of induction
Repetitive Transcranial Magnetic Stimulation as a Probe of Episodic Memory Neurocircuitry in Schizophrenia
This study proposes to combine functional magnetic resonance imaging (fMRI) with inhibitory Low Frequency (1 Hz) and excitatory High Frequency (20 Hz) repetitive Transcranial Magnetic Stimulationn (rTMS) in schizophrenia.
Neural correlates of consumers' mental imagery.
The purpose of this study is to investigate how the brain processes various stimuli in the context of consumer decision-making. This study will identify the neural correlates of consumers' mental imagery.
Randomized Phase II/III Trial of Radiotherapy with Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy with Concurrent Cetuximab in Patients with Stage III-IVB Head and Neck Cancer with a Contraindication to Cisplatin
The purpose of this study is to compare any good and bad effects of usual radiation plus the study treatment, MEDI4736 (durvalumab), to the usual therapy of radiation plus cetuximab in patients with head and neck cancer who cannot take the drug cisplatin.
The effect of foot type on ankle movement during an inversion perturbation
The proposed study aims to determine if different foot types have an impact on maximum inversion, time to maximum inversion, and inversion velocity during a dynamic perturbation task.
Insights into the Lid Margin: Characterization of Membrane Associated Mucins in Ocular Surface Disease
Dry eye disease affects millions of people worldwide and due to an incomplete understanding of the pathogenesis of the disease, it is widely underdiagnosed and undermanaged by clinicians. Understanding the contribution of the proteins involved in maintaining boundary lubrication between the ocular surface and eyelids, specifically mucins, may lead to …
An ERP Examination of Facial Affect Recognition
The purpose of this study is to examine the underlying neuronal correlates of facial recognition. We will specifically be examining how different faces correspond with brain activity and how features of personality impact the processing of faces and related brain activity.
Effects of Kinesio tape on Delayed Onset Muscle Soreness
The purpose of this study is to determine the effect of Kinesio tape on delayed onset muscle soreness of the biceps muscle of your arm following strenuous eccentric exercise of the bicep muscle. Delayed onset muscle soreness is the pain and stiffness felt in the muscles several hours to days …
Profiling Between-limb Differences for Prospectively Injured and Uninjured Runners: A Dynamical Measures Approach
The purpose of this study is: 1) to determine natural and healthy levels of movement pattern differences between the right and left limb 2) to determine whether these differences may be related to the risk of developing a running related injury.
