Found 168 clinical trials
Phase II Randomized Double-Blind Study of mFOLFIRINOX plus Ramucirumab versus mFOLFIRINOX plus placebo in Advanced Pancreatic Cancer Patients HCRN GI14-198
The purpose of this study is to find out what effects, good and/or bad, there are to adding the drug ramucirumab (RAM) to the usual chemotherapy regimen.
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- 19 Feb, 2024
- 1 location
A First-in-Human Phase I Trial to Determine the Safety and the Pharmacokinetic Profile of DSP-0337 in Patients With Advanced Solid Tumors
This is a Phase 1, open label, multi-center study of orally administered DSP-0337 in adult subjects with advance solid tumors that are refractory to standard treatment, or for whom no effective therapy exists.
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- 19 Feb, 2024
- 1 location
eFT508 in Combination With PD-1/PD-L1 Inhibitor Therapy: A Study of Subjects Administered Anti-PD-1/Anti-PD-L1 Therapy That Are Experiencing Insufficient Response to Checkpoint Inhibitor Alone
This study will evaluate the safety, tolerability, antitumor activity, and pharmacokinetics (PK) of eFT508 in patients who have initiated anti-PD-1/anti-PD-L1 monotherapy and either developed progressive disease (PD) on therapy or have undergone 12 weeks of anti-PD-1/anti-PD-L1 therapy with no evidence of partial response (PR) or complete response (CR).
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- 19 Feb, 2024
- 1 location
IUCRO-0209; The Susan G. Komen for a Cure Tissue Bank at IU Simon Cancer Center Collection and Storage of Biological Specimens Intended for Use in the Elucidation of Breast Carcinogenesis
The purpose of this study is to obtain and store specimens (tissue, blood, urine, or saliva) from subjects without diagnosed breast cancer compared to subjects with breast cancer.
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- 19 Feb, 2024
- 1 location
A Phase II Randomized Trial of Olaparib (NSC-747856) Administered Concurrently With Radiotherapy Versus Radiotherapy Alone for Inflammatory Breast Cancer
This phase II trial studies how well radiation therapy with or without olaparib works in treating patients with inflammatory breast cancer.
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- 19 Feb, 2024
- 1 location
Feasibility, Acceptability and Preliminary Effects of the Spiritual Care Assessment and Intervention (SCAI) Framework for Adults With Advanced Cancer and Their Caregivers (FCGs): A Clinical Pilot Trial
The purpose of this study is to test a spiritual care intervention for adults with advanced cancer and their caregivers.
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- 19 Feb, 2024
- 1 location
Phase 3 Accelerated BEP Trial: A randomised phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours
The purpose of this study is to determine if accelerated BEP will be more effective but not significantly more toxic than standard BEP.
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- 19 Feb, 2024
- 1 location
A Phase 2 Study of Sitravatinib in Combination with Nivolumab in Patients with Advanced or Metastatic Urothelial Carcinoma
The purpose of this study is to evaluate the clinical activity of sitravatinib in combination with nivolumab in patients with advanced or metastatic urothelial carcinoma.
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- 19 Feb, 2024
- 1 location
A RANDOMIZED, PHASE II STUDY COMPARING TRASTUZUMAB AND VINORELBINE IN COMBINATION WITH AVELUMAB OR AVELUMAB AND UTOMILUMAB (41BB/CD137 AGONIST), IN PATIENTS WITH HER2-POSITIVE METASTATIC BREAST CANCER WHO HAVE PROGRESSED ON PRIOR TRASTUZUMAB AND PERTUZUMAB: The "AVIATOR" Study
To determine whether the addition of avelumab to the combination of trastuzumab and vinorelbine will improve progression-free survival (PFS) compared to the trastuzumab and vinorelbine combination alone in patients with advanced HER2-positive breast cancer. To determine whether the addition of utomilumab to the combination of avelumab, trastuzumab, and vinorelbine will …
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- 19 Feb, 2024
- 1 location
Developing the Breast Cancer Self-Efficacy Scale for Partners (BCSES-P)
Normal 0 false false false EN-US JA X-NONE Are you, or is someone you know, a partner of a breast cancer survivor? Breast cancer can be a scary and hard situation for your significant other and for YOU. Partners experience a lot of stress after the diagnosis. Finding ways …
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- 19 Feb, 2024
- 1 location