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A Phase II Study of Cabozantinib (XL184) for Plexiform Neurofibromas in Subjects With Neurofibromatosis Type 1 in Children and Adults

Study of Investigational Medication for Neurofibromatosis Type 1 with Plexiform Neurofibromas

Recruiting
3 years and older
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates the effectiveness of an investigational medication for treating plexiform neurofibromas in patients with neurofibromatosis type 1 (NF1). Neurofibromatosis type 1 is a genetic disorder that causes tumors to form on nerve tissue, and plexiform neurofibromas are a type of tumor that can grow along nerves. The purpose of this study is to see how well the tumors respond to the treatment using MRI scans.

Participants in the study will receive the investigational medication and undergo MRI scans to monitor the size of their tumors. MRI, or Magnetic Resonance Imaging, is a technique that uses magnets and radio waves to create detailed images of the inside of the body. This helps doctors see how the treatment is affecting the tumors.

  • Who can participate: Individuals diagnosed with neurofibromatosis type 1 and have plexiform neurofibromas that are growing or causing problems can participate. Participants must have measurable disease suitable for MRI imaging and must have recovered from previous treatments.
  • Study details: Participants will take the investigational medication in tablet form. A placebo is not used in this study. Participants must be able to swallow tablets and will undergo MRI scans to assess the effects of the treatment.
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Study details
    Neurofibromatosis Type 1
    Plexiform Neurofibromas
    Neurofibromatosis Type 1
    Neurofibromatosis Type I
    Plexiform Neurofibroma
    Neurofibroma
    Neurofibromas
    Neurofibromatosis

TX3396

19 February 2024

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